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Socs3tm1Jni
Targeted Allele Detail
Nomenclature
Symbol: Socs3tm1Jni
Name: suppressor of cytokine signaling 3; targeted mutation 1, James N Ihle
MGI ID: MGI:2181439
Synonyms: SOCS-3 -, SOCS3-, Socs3tm11Jni
Gene: Socs3  Location: Chr11:117966079-117970047 bp, - strand  Genetic Position: Chr11, 82.96 cM, cytoband E2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:57476
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region of the gene was replaced with a neomycin resistance cassette by homologous recombination. Homozygous embryos lacked gene expression as determined by immunofluorescent staining of erythroid progenitor cells. (J:57476)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 6 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Socs3 Mutation:  8 strains or lines available
Notes
The embryonic lethality observed in homozygotes is rescued by tetraploid fusion with wild-type trophoblast stem cells (J:112739).
References
Original:  J:57476 Marine JC, et al., SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell. 1999 Sep 3;98(5):617-27
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory