All Phenotypes Socs3<tm1Jni> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Socs3^tm1Jni/Socs3^tm1Jni	involves: 129P2/OlaHsd	MGI:3783722
hm2	Socs3^tm1Jni/Socs3^tm1Jni	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:3783726
ht3	Socs3^tm1Jni/Socs3⁺	B6.129P2-Socs3^tm1Jni	MGI:3783734
ht4	Socs3^tm1Jni/Socs3⁺	involves: 129P2/OlaHsd	MGI:3783730
ht5	Socs3^tm1Jni/Socs3⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3783733

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:57476 )

• mice continue to die through E16.5 when only 1 is recovered

embryonic lethality during organogenesis, incomplete penetrance ( J:57476 )

• mice exhibit embryonic lethality beginning at E12

hematopoietic system

hematopoietic system phenotype ( J:57476 )

N	• despite disruptions in embryonic erythropoiesis, adult hematopoiesis is normal in irradiated mice reconstituted with Socs3^tm1Jni cells

abnormal embryonic erythropoiesis ( J:57476 )

• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells

• in a colony-forming assay, the number of erythroid colony-forming cells, burst-forming cells and IL-3 sensitive multilineage progenitors is decreased 10-fold compared to wild-type while colony size is typically 5 to 10 times larger than colonies from wild type mice

increased erythrocyte cell number ( J:57476 )

• at E12.5, mice exhibit erythrocytosis that increases in frequency with age

increased nucleated erythrocyte cell number ( J:57476 )

• most erythrocytes are still nucleated unlike in wild-type mice

liver/biliary system

abnormal liver morphology ( J:57476 )

• at E12.5, the fetal liver is distorted with an excess of erythroid cells

embryo

decreased embryo size ( J:57476 )

abnormal embryonic erythropoiesis ( J:57476 )

• embryos exhibit a shift from more immature populations to more mature, non-proliferative populations of erythroid cells

growth/size/body

decreased embryo size ( J:57476 )

integument

reddish skin ( J:57476 )

• mice exhibit erythmia throughout the embryo including the head and lens of the eye

Allelic Composition	Socs3^tm1Jni/Socs3^tm1Jni
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3^tm1Jni mutation (0 available); any Socs3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

abnormal placenta labyrinth morphology ( J:112739 )

• giant cells occupy the labyrinth and there is no labyrinthine layers unlike in wild-type mice

Allelic Composition	Socs3^tm1Jni/Socs3⁺
Genetic Background	B6.129P2-Socs3^tm1Jni

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3^tm1Jni mutation (0 available); any Socs3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:91797 )

improved glucose tolerance ( J:91797 )

• mice exhibit improved glucose tolerance compared to wild-type mice when fed a high fat diet

increased insulin sensitivity ( J:91797 )

• on a regular or high fat diet

growth/size/body

decreased susceptibility to diet-induced obesity ( J:91797 )

Allelic Composition	Socs3^tm1Jni/Socs3⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3^tm1Jni mutation (0 available); any Socs3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased interleukin-2 secretion ( J:128797 )

• CD-28 mediated IL-2 production is 2-fold higher than in wild-type cells

• however, TCR-mediated IL-2 production is normal

Allelic Composition	Socs3^tm1Jni/Socs3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3^tm1Jni mutation (0 available); any Socs3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:91797 )

decreased circulating leptin level ( J:91797 )

• when placed on a high fat diet mice do not exhibit an increase in leptin levels compared to wild-type mice

growth/size/body

weight loss ( J:91797 )

• unlike wild-type mice, treatment with leptin results in weight loss despite equivalent leptin serum levels

decreased susceptibility to diet-induced obesity ( J:91797 )

adipose tissue

decreased total body fat amount ( J:91797 )

• when treated with leptin

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