Cldn11^tm1Ral
Targeted Allele Detail

Summary

• Symbol: Cldn11^tm1Ral
• Name: claudin 11; targeted mutation 1, Robert A Lazzarini
• MGI ID: MGI:2181029
• Synonyms: OSP/claudin-11 (-)
• Gene: Cldn11 Location: Chr3:31204069-31218473 bp, + strand Genetic Position: Chr3, 15.14 cM
• Alliance: Cldn11^tm1Ral page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59025
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A construct containing a promoterless lacZ gene and a floxed PGK-neomycin resistance gene replaced exon 1 and a portion of intron 1. Northern blot analysis of extracts from brains and testes showed a lack of transcript in homozygous mutant mice. Western blot analysis confirmed an absence of encoded protein in brain homogenates. Expression of the inserted lacZ gene was under the control of the endogenous promoter. (J:59025)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cldn11 Mutation: 15 strains or lines available

References

• Original: J:59025 Gow A, et al., CNS myelin and sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell. 1999 Dec 10;99(6):649-59
• All: 8 reference(s)