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Clutm1Jakh
Targeted Allele Detail
Nomenclature
Symbol: Clutm1Jakh
Name: clusterin; targeted mutation 1, Judith A K Harmony
MGI ID: MGI:2181011
Synonyms: CLU-
Gene: Clu  Location: Chr14:65968483-65981548 bp, + strand  Genetic Position: Chr14, 34.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65660
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn HPRT cassette replaced exons 1 and 2. Normal transcript was undetectable in homozygous mutant tissue. Western blot analysis of plasma and liver extracts showed an absence of protein in homozygous mutant mice. (J:2892, J:65660, J:67960)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Clu Mutation:  19 strains or lines available
References
Original:  J:65660 McLaughlin L, et al., Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis. J Clin Invest. 2000 Nov;106(9):1105-13
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory