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Targeted Allele Detail
Symbol: Prkacbtm1Gsm
Name: protein kinase, cAMP dependent, catalytic, beta; targeted mutation 1, G Stanley McKnight
MGI ID: MGI:2180946
Synonyms: Cbeta1-
Gene: Prkacb  Location: Chr3:146729579-146812946 bp, - strand  Genetic Position: Chr3, 72.28 cM, cytoband H3
Neural tube defects in Prkacatm1Gsm/Prkaca+ Prkacbtm1Gsm/Prkacbtm1Gsm and Prkacatm1Gsm/Prkacatm1Gsm Prkacbtm1Gsm/Prkacb+ mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:31731
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 200 bp region of the gene spanning amino acid 5 of exon 1 to part of intron 1 was replaced with a neomycin resistance cassette via homologous recombination. The gene targeting event specifically disrupts the beta 1 isoform of the gene product. The beta 2 and beta 3 isoforms, which do not utilize exon 1, remain intact. Western blot analysis verified the absence of beta 1 isoform in homozygous mutant animals. (J:31731)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkacb Mutation:  17 strains or lines available
ES cell line = REK2 or REK3.
Original:  J:31731 Qi M, et al., Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1571-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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