About   Help   FAQ
Prkacbtm1Gsm
Targeted Allele Detail
Nomenclature
Symbol: Prkacbtm1Gsm
Name: protein kinase, cAMP dependent, catalytic, beta; targeted mutation 1, G Stanley McKnight
MGI ID: MGI:2180946
Synonyms: Cbeta1-
Gene: Prkacb  Location: Chr3:146729579-146812946 bp, - strand  Genetic Position: Chr3, 72.28 cM, cytoband H3
Neural tube defects in Prkacatm1Gsm/Prkaca+ Prkacbtm1Gsm/Prkacbtm1Gsm and Prkacatm1Gsm/Prkacatm1Gsm Prkacbtm1Gsm/Prkacb+ mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31731
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 200 bp region of the gene spanning amino acid 5 of exon 1 to part of intron 1 was replaced with a neomycin resistance cassette via homologous recombination. The gene targeting event specifically disrupts the beta 1 isoform of the gene product. The beta 2 and beta 3 isoforms, which do not utilize exon 1, remain intact. Western blot analysis verified the absence of beta 1 isoform in homozygous mutant animals. (J:31731)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Prkacb Mutation:  17 strains or lines available
Notes
ES cell line = REK2 or REK3.
References
Original:  J:31731 Qi M, et al., Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1996 Feb 20;93(4):1571-6
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/16/2021
MGI 6.16
The Jackson Laboratory