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Cd81tm1Geha
Targeted Allele Detail
Summary
Symbol: Cd81tm1Geha
Name: CD81 antigen; targeted mutation 1, Raif S Geha
MGI ID: MGI:2180813
Gene: Cd81  Location: Chr7:142606487-142621667 bp, + strand  Genetic Position: Chr7, 88.1 cM
Alliance: Cd81tm1Geha page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43975
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exons 2 through 8, comprising the majority of the coding sequence. FACS analysis showed a lack of cell surface protein expression on thymocytes isolated from homozygous mutant mice. (J:43975)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd81 Mutation:  21 strains or lines available
References
Original:  J:43975 Tsitsikov EN, et al., Impaired CD19 expression and signaling, enhanced antibody response to type II T independent antigen and reduction of B-1 cells in CD81-deficient mice. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10844-9
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory