Analysis Tools
immune system
|
• less than 20% of B cells mobilize calcium after CD19-ligation compared to over 95% of wild-type B cells
• B cells are less sensitive than wild-type B cells to inhibition by CD19
• B cells have significantly enhanced antibody response to the type II T cell-independent antigen TNP-Ficoll in both IgM and IgG3 isotypes
|
|
• surface expression of the B cell marker CD19 is reduced by about 50% compared to controls
• expression of other B cell markers is normal
|
|
• there is a 80% reduction of B-1 B cells in the peritoneal cavity
|
|
• the reduction in B-1 B cells is partially caused by a severe decrease in B-1a B cell numbers
|
|
• as mice age IgA levels increase until they are 3- to 4-fold higher than controls at 14 weeks of age
|
|
• mice have enhanced IgG3 response to immunization with type II T cell independent antigens
|
|
• as mice age IgM levels increase until they are 3- to 4-fold higher than controls at 14 weeks of age
• mice also have enhanced IgM response to immunization with type II T cell independent antigens
|
behavior/neurological
|
• mice do not exhibit preference for a chamber associated with cocaine administration after one day of testing
• controls exhibit an association for at least three days
• mice are less active than controls at low doses of cocaine
|
|
• female mice exhibit less activity than controls
• no significant differences are observed in the activity of male mice
|
nervous system
|
• there is a significant increase in the concentration of dopamine in the accumbens of male but not female mice
|
hematopoietic system
|
• less than 20% of B cells mobilize calcium after CD19-ligation compared to over 95% of wild-type B cells
• B cells are less sensitive than wild-type B cells to inhibition by CD19
• B cells have significantly enhanced antibody response to the type II T cell-independent antigen TNP-Ficoll in both IgM and IgG3 isotypes
|
|
• surface expression of the B cell marker CD19 is reduced by about 50% compared to controls
• expression of other B cell markers is normal
|
|
• there is a 80% reduction of B-1 B cells in the peritoneal cavity
|
|
• the reduction in B-1 B cells is partially caused by a severe decrease in B-1a B cell numbers
|
|
• as mice age IgA levels increase until they are 3- to 4-fold higher than controls at 14 weeks of age
|
|
• mice have enhanced IgG3 response to immunization with type II T cell independent antigens
|
|
• as mice age IgM levels increase until they are 3- to 4-fold higher than controls at 14 weeks of age
• mice also have enhanced IgM response to immunization with type II T cell independent antigens
|
homeostasis/metabolism
|
• there is a significant increase in the concentration of dopamine in the accumbens of male but not female mice
|
cellular
|
• less than 20% of B cells mobilize calcium after CD19-ligation compared to over 95% of wild-type B cells
• B cells are less sensitive than wild-type B cells to inhibition by CD19
• B cells have significantly enhanced antibody response to the type II T cell-independent antigen TNP-Ficoll in both IgM and IgG3 isotypes
|
