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Cd81tm1Lvy
Targeted Allele Detail
Nomenclature
Symbol: Cd81tm1Lvy
Name: CD81 antigen; targeted mutation 1, Shoshana Levy
MGI ID: MGI:2180805
Synonyms: CD81-
Gene: Cd81  Location: Chr7:143052739-143067934 bp, + strand  Genetic Position: Chr7, 88.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40394
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exons 2 through 8. Flow cytometric analysis of protein surface expression detected only background levels of staining in thymocytes isolated from homozygous mutant mice. (J:40394)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd81 Mutation:  14 strains or lines available
References
Original:  J:40394 Maecker HT, et al., Normal lymphocyte development but delayed humoral immune response in CD81-null mice. J Exp Med. 1997 Apr 21;185(8):1505-10
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory