About   Help   FAQ
Cdc45tm1Dta
Targeted Allele Detail
Nomenclature
Symbol: Cdc45tm1Dta
Name: cell division cycle 45; targeted mutation 1, Anindya Dutta
MGI ID: MGI:2180780
Synonyms: CDC45-
Gene: Cdc45  Location: Chr16:18780447-18811987 bp, - strand  Genetic Position: Chr16, 11.63 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70008
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection gene replaced exons 1 and 2, which encode the 199 amino-terminal residues. RT-PCR analysis of total RNA obtained from heterozygous mutant embryos showed that the level of normal transcript was approximately half of what was detected in wild-type embryos. (J:70008)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc45 Mutation:  17 strains or lines available
References
Original:  J:70008 Yoshida K, et al., Requirement of CDC45 for postimplantation mouse development. Mol Cell Biol. 2001 Jul;21(14):4598-603
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory