Phenotypes associated with this allele

• Allele Symbol: Cdc45^tm1Dta
• Allele Name: targeted mutation 1, Anindya Dutta
• Allele ID: MGI:2180780
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdc45^tm1Dta/Cdc45^tm1Dta	involves: 129S4/SvJae * C57BL/6	MGI:2662265
ht2	Cdc45^tm1Dta/Cdc45^+	involves: 129S4/SvJae * C57BL/6	MGI:2450920

Genotype
MGI:2662265

hm1

• Allelic Composition: Cdc45^tm1Dta/Cdc45^tm1Dta
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:70008 )

• homozygous embryos die between E4.5 and E5.5 around the time of implantaton

embryo

absent inner cell mass proliferation ( J:70008 )

• cells of the inner cell mass did not proliferate in cultured blastocysts

cellular

absent inner cell mass proliferation ( J:70008 )

• cells of the inner cell mass did not proliferate in cultured blastocysts

Genotype
MGI:2450920

ht2

• Allelic Composition: Cdc45^tm1Dta/Cdc45⁺
• Genetic Background: involves: 129S4/SvJae * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:70008 )

• heterozygous mice are of normal size, exhibit normal behavior, and are fertile