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Cd22tm1Lam
Targeted Allele Detail
Nomenclature
Symbol: Cd22tm1Lam
Name: CD22 antigen; targeted mutation 1, Marinus C Lamers
MGI ID: MGI:2180698
Synonyms: CD22-
Gene: Cd22  Location: Chr7:30865404-30880342 bp, - strand  Genetic Position: Chr7, 19.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38644
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 11, encoding the transmembrane domain, was disrupted by the insertion of a neomycin cassette. Flow cytometric analysis showed an absence of surface expression on splenocytes isolated from homozygous mutant mice. (J:38644)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd22 Mutation:  38 strains or lines available
References
Original:  J:38644 Nitschke L, et al., CD22 is a negative regulator of B-cell receptor signalling. Curr Biol. 1997 Feb 1;7(2):133-43
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory