About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cd22tm1Lam
targeted mutation 1, Marinus C Lamers
MGI:2180698
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cd22tm1Lam/Cd22tm1Lam involves: 129 * C57BL/6 MGI:3760846
cx2
 		Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Ightm1.2Rsky 		involves: 129 * BALB/c * C57BL/6 MGI:3760847
cx3
 		Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Igh+ 		involves: 129 * BALB/c * C57BL/6 MGI:3760862


Genotype
MGI:3760846
hm1
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:125719 )
• reduction of recirculating mature B cells in the bone marrow
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization upon activation of B cells

hematopoietic system
decreased mature B cell number ( J:125719 )
• reduction of recirculating mature B cells in the bone marrow
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization upon activation of B cells




Genotype
MGI:3760847
cx2
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Ightm1.2Rsky
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (59 available)
Ightm1.2Rsky mutation (0 available); any Igh mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased B-1a cell number ( J:125719 )
• 5 fold reduction in the peritoneum
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization to high levels upon activation of B cells

hematopoietic system
decreased B-1a cell number ( J:125719 )
• 5 fold reduction in the peritoneum
abnormal B cell activation ( J:125719 )
• enhanced Ca2+ mobilization to high levels upon activation of B cells




Genotype
MGI:3760862
cx3
Allelic
Composition		 Cd22tm1Lam/Cd22tm1Lam
Ightm1.2Rsky/Igh+
Genetic
Background		 involves: 129 * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd22tm1Lam mutation (1 available); any Cd22 mutation (59 available)
Ightm1.2Rsky mutation (0 available); any Igh mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:125719 )
• the percentage of B cells with surface IgG1 expression is doubled compared to mutant mice on a CD22-proficient background

hematopoietic system
abnormal class switch recombination ( J:125719 )
• the percentage of B cells with surface IgG1 expression is doubled compared to mutant mice on a CD22-proficient background




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory