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Cd19tm1Tft
Targeted Allele Detail
Nomenclature
Symbol: Cd19tm1Tft
Name: CD19 antigen; targeted mutation 1, Thomas F Tedder
MGI ID: MGI:2180685
Synonyms: CD19-
Gene: Cd19  Location: Chr7:126408450-126414889 bp, - strand  Genetic Position: Chr7, 69.01 cM, cytoband F3-F4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:27236
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 5 encoding the transmembrane domain and 7 of the 9 exons encoding cytoplamic domains were replaced with a neomycin cassette. In addition, the inserted neomycin gene introduced a stop codon. Immunohistochemical staining showed a lack of protein expression in the spleens of homozygous mutant mice. (J:27236, J:100523)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd19 Mutation:  16 strains or lines available
References
Original:  J:27236 Engel P, et al., Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. Immunity. 1995 Jul;3(1):39-50
All:  32 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory