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Cxcr3tm1Wwh
Targeted Allele Detail
Nomenclature
Symbol: Cxcr3tm1Wwh
Name: chemokine (C-X-C motif) receptor 3; targeted mutation 1, Wayne W Hancock
MGI ID: MGI:2180682
Synonyms: Cxcr3-, CXCR3-, CXCR3-KO
Gene: Cxcr3  Location: ChrX:101731535-101734269 bp, - strand  Genetic Position: ChrX, 44.58 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65916
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details800 bp of exon 2 was replaced with a PGK-neo cassette via homologous recombination. T cells from homozygous mutant animals lack gene expression and do not exhibit chemotaxis as assessed by RNase protection and chemotaxis assays, respectively. (J:65916)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxcr3 Mutation:  3 strains or lines available
Notes
ES cell line = ES-1.

References
Original:  J:65916 Hancock WW, et al., Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J Exp Med. 2000 Nov 20;192(10):1515-20
All:  87 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory