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Ctla4tm1Shr
Targeted Allele Detail
Nomenclature
Symbol: Ctla4tm1Shr
Name: cytotoxic T-lymphocyte-associated protein 4; targeted mutation 1, Arlene H Sharpe
MGI ID: MGI:2180668
Synonyms: Ctla4-, CTLA-4-
Gene: Ctla4  Location: Chr1:60909025-60915832 bp, + strand  Genetic Position: Chr1, 30.58 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30393
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a PGK-neo cassette replaced a 1.3 kb region containing exon 2 and a portion of exon 3. The deleted region encoded a IgV and part of a transmembrane domain. Fluorescence-activated cell sorting (FACS) analysis showed an absence of protein in splenocytes isolated from homozygous mutant mice. (J:30393)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ctla4 Mutation:  25 strains or lines available
References
Original:  J:30393 Tivol EA, et al., Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity. 1995 Nov;3(5):541-7
All:  41 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory