Otp^tm1Asim
Targeted Allele Detail

Summary

• Symbol: Otp^tm1Asim
• Name: orthopedia homeobox; targeted mutation 1, Antonio Simeone
• MGI ID: MGI:2180541
• Synonyms: Otp^-
• Gene: Otp Location: Chr13:95012144-95021633 bp, + strand Genetic Position: Chr13, 49.22 cM
• Alliance: Otp^tm1Asim page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:58466
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 1 and all of exon 2 were replaced with a construct containing both neo and lacZ genes. Western analysis showed an absence of the endogenous protein in extracts from homozygous mutant embyros. Expression of the inserted lacZ gene was found to be identical to the expression of the endogenous gene. (J:58466)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otp Mutation: 16 strains or lines available

References

• Original: J:58466 Acampora D, et al., Progressive impairment of developing neuroendocrine cell lineages in the hypothalamus of mice lacking the Orthopedia gene. Genes Dev. 1999 Nov 1;13(21):2787-800
• All: 5 reference(s)