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Nhlh2tm1Irk
Targeted Allele Detail
Nomenclature
Symbol: Nhlh2tm1Irk
Name: nescient helix loop helix 2; targeted mutation 1, Ilan R Kirsch
MGI ID: MGI:2180391
Synonyms: Nhlh2-
Gene: Nhlh2  Location: Chr3:102010111-102015492 bp, + strand  Genetic Position: Chr3, 44.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:39356
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe entire coding region was replaced with a PGK-neo cassette. Transcript was undetected by Northern blot analysis of total RNA isolated from homozygous mutant embryos. (J:39356)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nhlh2 Mutation:  4 strains or lines available
References
Original:  J:39356 Good DJ, et al., Hypogonadism and obesity in mice with a targeted deletion of the Nhlh2 gene. Nat Genet. 1997 Apr;15(4):397-401
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory