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Actbtm1Bhr
Targeted Allele Detail
Nomenclature
Symbol: Actbtm1Bhr
Name: actin, beta; targeted mutation 1, Richard R Behringer
MGI ID: MGI:2180089
Gene: Actb  Location: Chr5:142903115-142906754 bp, - strand  Genetic Position: Chr5, 81.8 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:46634
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA promoterless hygromycin-lacZ fusion gene with a splice acceptor was introduced into the first intron of the beta actin locus. The presence of normal transcript in homozygous mutants suggests that the fusion gene is sporadically excised during splicing, resulting in a hypomorphic allele. Expression analysis indicated that the integration event does not result in ubiquitous expression of Beta galactosidase. (J:46634)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Actb Mutation:  28 strains or lines available
References
Original:  J:46634 Shawlot W, et al., Restricted beta-galactosidase expression of a hygromycin-lacZ gene targeted to the beta-actin locus and embryonic lethality of beta-actin mutant mice. Transgenic Res. 1998 Mar;7(2):95-103
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory