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Targeted Allele Detail
Symbol: F8tm2Kaz
Name: coagulation factor VIII; targeted mutation 2, Haig H Kazazian Jr
MGI ID: MGI:2179968
Synonyms: E17, MFVIII-17
Gene: F8  Location: ChrX:75172715-75382615 bp, - strand  Genetic Position: ChrX, 38.17 cM, cytoband A7-B
Germline Transmission:  Earliest citation of germline transmission: J:24941
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Single point mutation
Mutation detailsInsertion of a neomycin resistance cassette into exon 17 and introduction of a single nucleotide substitution at a site 19 bp 3' to the 5' end of the exon. Two different activity assays indicated that the mutated allele produced protein with levels of activity less than 1% of wild-type levels. (J:24941)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any F8 Mutation:  16 strains or lines available
Original:  J:24941 Bi L, et al., Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A [letter]. Nat Genet. 1995 May;10(1):119-21
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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