Analysis Tools
homeostasis/metabolism
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• after tail cut, blood loss is greater than in wild-type mice
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Allele Symbol Allele Name Allele ID |
F8tm2Kaz targeted mutation 2, Haig H Kazazian Jr MGI:2179968 |
| Summary |
3 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after tail cut, blood loss is greater than in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after tail cut, blood loss is greater than in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• males exhibit hemophilia
(J:24941)
• mice exhibit a reduced ability to clot blood upon tail cutting, with most animals dying within 2 hours of tail snipping unless cauterized; however, no spontaneous bleeding is observed into joints or soft tissues up to 12 weeks of age
(J:24941)
• plasma from mutant mice exhibits a prolonged clotting time compared to controls
(J:24941)
• females exhibit normal fertility and pregnancy
(J:36698)
• males exhibit no spontaneous bleeding, illness or reduction in activity up to 1 year of age
(J:36698)
• 2/3 males die within 2 hours of tail snipping from excessive bleeding
(J:36698)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| factor VIII deficiency | DOID:12134 |
OMIM:306700 |
J:24941 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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