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Targeted Allele Detail
Symbol: Fliitm1Hdc
Name: flightless I actin binding protein; targeted mutation 1, Hugh D Campbell
MGI ID: MGI:2179825
Synonyms: FliI-, Fliih-
Gene: Flii  Location: Chr11:60714123-60727263 bp, - strand  Genetic Position: Chr11, 37.81 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:76249
Parent Cell Line:  BALB/c-I (ES Cell)
Strain of Origin:  BALB/cJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPortions of exons 4 and 5 and all of intron 4 are replaced with an in-frame neo-resistance gene. Cryptic splicing around the insertion will result in a frameshift in the coding region. (J:76249)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Flii Mutation:  38 strains or lines available
Original:  J:76249 Campbell HD, et al., Fliih, a gelsolin-related cytoskeletal regulator essential for early mammalian embryonic development. Mol Cell Biol. 2002 May;22(10):3518-26
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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