Phenotypes associated with this allele

• Allele Symbol: Flii^tm1Hdc
• Allele Name: targeted mutation 1, Hugh D Campbell
• Allele ID: MGI:2179825
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Flii^tm1Hdc/Flii^tm1Hdc	involves: BALB/cJ * C57BL/6	MGI:3796832
ht2	Flii^tm1Hdc/Flii^+	involves: BALB/cJ * C57BL/6	MGI:3796831

Genotype
MGI:3796832

hm1

• Allelic Composition: Flii^tm1Hdc/Flii^tm1Hdc
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality at implantation, complete penetrance ( J:76249 )

• no embryos are recovered after E5.5; embryos develop normally until cellularization, the development arrests before completion of gastrulation

• blastocysts initiate uterine implantation but embryos fail to develop

embryo

embryonic growth arrest ( J:76249 )

• development arrests during gastrulation

Genotype
MGI:3796831

ht2

• Allelic Composition: Flii^tm1Hdc/Flii⁺
• Genetic Background: involves: BALB/cJ * C57BL/6

homeostasis/metabolism

enhanced wound healing ( J:119983 )

• 3 days after a 1 cm full-thickness incision was made in the dorsal skin, surface wound area measurements show smaller, more contracted wounds than in wild-type mice

• length of neoepidermis is significantly greater in mutant animals, and percentage or re-epithelialization of wounds is greater at 5 days after wounding

• by day 7, healing is comparable in mutants and wild-type