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Trpc2tm1Rax
Targeted Allele Detail
Nomenclature
Symbol: Trpc2tm1Rax
Name: transient receptor potential cation channel, subfamily C, member 2; targeted mutation 1, Richard Axel
MGI ID: MGI:2179812
Synonyms: trp2-
Gene: Trpc2  Location: Chr7:102083116-102096396 bp, + strand  Genetic Position: Chr7, 54.71 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76339
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 6.1 kb region of this gene, which includes exons 6-11 and encodes transmembrane domains 3-6, was replaced with a PGK-neo cassette via homologous recombination. In situ hybridization of the vomeronasal organ (VNO) from homozygous mutant animals did not detect gene transcript. Immunohistochemical staining of vomeronasal neuron cell bodies from homozygous mutant animals did not detect protein product. (J:76339)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trpc2 Mutation:  87 strains or lines available
References
Original:  J:76339 Leypold BG, et al., Altered sexual and social behaviors in trp2 mutant mice. Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):6376-81
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory