Sv2a^tm1Baj
Targeted Allele Detail

Summary

• Symbol: Sv2a^tm1Baj
• Name: synaptic vesicle glycoprotein 2a; targeted mutation 1, Sandra M Bajjalieh
• MGI ID: MGI:2179735
• Gene: Sv2a Location: Chr3:96088543-96102499 bp, + strand Genetic Position: Chr3, 41.65 cM, cytoband F2
• Alliance: Sv2a^tm1Baj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59073
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced a genomic fragment including the exon containing the translation initiation codon. Western blot analysis on brain extracts derived from homozygous mice confirmed that no detectable encoded protein was present. (J:59073)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Sv2a Mutation: 36 strains or lines available

References

• Original: J:59073 Crowder KM, et al., Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):15268-73
• All: 9 reference(s)