Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Baj mutation
(2 available);
any
Sv2a mutation
(36 available)
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cellular
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• exocytosis burst is reduced to about 52% of wild-type levels and response to a second wave of calcium is even smaller at 35% of wild-type levels
• SNARE (soluble N-ethylmaleimide sensitive fusion attachment receptor) complexes are decreased in the brain
• however, exocytotic vesicle size and number are normal
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nervous system
growth/size/body
behavior/neurological
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Baj mutation
(2 available);
any
Sv2a mutation
(36 available)
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mortality/aging
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• animals die between P12 and P23
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behavior/neurological
growth/size/body
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• at P7, animals stop growing and are approximately half the size of littermates by P9
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nervous system
N |
• normal brain morphology
• normal synaptic density
• normal synaptic morphology
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• IPSCs in pyramidal neurons of the CA3 region of the hippocampus had reduced frequency and amplitude
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Allelic Composition |
Sv2atm1Baj/Sv2a+
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Genetic Background |
Not Specified |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sv2atm1Baj mutation
(2 available);
any
Sv2a mutation
(36 available)
|
|
|
mortality/aging
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• incomplete penetrance; some percentage of animals die between the 2nd through 6th month of life
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behavior/neurological
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• incomplete penetrance; seen in 24% of animals
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nervous system
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• incomplete penetrance; seen in 24% of animals
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cellular
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• exocytosis burst is reduced to about 52% of wild-type levels and response to a second wave of calcium is even smaller at 35% of wild-type levels
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nervous system
growth/size/body
behavior/neurological
mortality/aging
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• mice die within 3 weeks of birth as in Sv2atm1Baj Sv2btm1Baj double homozygotes
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growth/size/body
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• mice fail to grow as in Sv2atm1Baj Sv2btm1Baj double homozygotes
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