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Ccr6tm1Gma
Targeted Allele Detail
Nomenclature
Symbol: Ccr6tm1Gma
Name: chemokine (C-C motif) receptor 6; targeted mutation 1, Gabriel Marquez
MGI ID: MGI:2179613
Synonyms: CCR6-
Gene: Ccr6  Location: Chr17:8236043-8257141 bp, + strand  Genetic Position: Chr17, 4.9 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68191
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced most of the coding exon, leaving the sequences that encode the 25 carboxy terminal amino acids. Northern analysis of spleen and thymus did not detect mRNA in homozygous mutant mice. (J:68191)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ccr6 Mutation:  20 strains or lines available
References
Original:  J:68191 Varona R, et al., CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses. J Clin Invest. 2001 Mar;107(6):R37-45
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory