About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccr6tm1Gma
targeted mutation 1, Gabriel Marquez
MGI:2179613
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccr6tm1Gma/Ccr6tm1Gma involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3621959
cx2
 		Ccr6tm1Gma/Ccr6tm1Gma
Tg(Rorc-EGFP)1Ebe/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3829420


Genotype
MGI:3621959
hm1
Allelic
Composition		 Ccr6tm1Gma/Ccr6tm1Gma
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Gma mutation (3 available); any Ccr6 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased leukocyte cell number ( J:68191 )
• mice have a decreased number of leukocytes in Peyer's patches compared to wild-type
increased leukocyte cell number ( J:68191 )
• there is a 2 fold increase in total lymphocytes in the intraepithelial lymphocyte subpopulation
abnormal myeloid dendritic cell morphology ( J:68191 )
• subpopulations of myeloid dendritic cells are aberrantly positioned compared to wild-type
abnormal CD4-positive, alpha-beta T cell physiology ( J:68191 )
• host mice are unable to develop an inflammatory response when injected with CD4+ T cells from null animals
abnormal Peyer's patch morphology ( J:68191 )
• mice have underdeveloped Peyer's patches compared to wild-type
abnormal Peyer's patch follicle morphology ( J:68191 )
• Peyer's patches from mutants show a lower number of developed follicles than wild-type animals
decreased inflammatory response ( J:68191 )
• sensitized null mice show less inflammation to subsequent injection of allogeneic splenocytes

hematopoietic system
decreased leukocyte cell number ( J:68191 )
• mice have a decreased number of leukocytes in Peyer's patches compared to wild-type
increased leukocyte cell number ( J:68191 )
• there is a 2 fold increase in total lymphocytes in the intraepithelial lymphocyte subpopulation
abnormal myeloid dendritic cell morphology ( J:68191 )
• subpopulations of myeloid dendritic cells are aberrantly positioned compared to wild-type
abnormal CD4-positive, alpha-beta T cell physiology ( J:68191 )
• host mice are unable to develop an inflammatory response when injected with CD4+ T cells from null animals




Genotype
MGI:3829420
cx2
Allelic
Composition		 Ccr6tm1Gma/Ccr6tm1Gma
Tg(Rorc-EGFP)1Ebe/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Gma mutation (3 available); any Ccr6 mutation (36 available)
Tg(Rorc-EGFP)1Ebe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased

hematopoietic system
abnormal effector T cell morphology ( J:137020 )
• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory