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Targeted Allele Detail
Symbol: Slit2tm1Matl
Name: slit guidance ligand 2; targeted mutation 1, Marc Tessier-Lavigne
MGI ID: MGI:2179460
Synonyms: Slit2-
Gene: Slit2  Location: Chr5:47983138-48307733 bp, + strand  Genetic Position: Chr5, 26.05 cM
Germline Transmission:  Earliest citation of germline transmission: J:73904
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsInsertion of a floxed PGK-neomycin resistance cassette preceded by an inframe stop codon, an IRES element, and sequences encoding a tauGFP fusion protein, deleted part of two 5' exons including the putative signal sequence (SS) and sequences encoding part of the first leucine rich repeat. (J:73904)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 77 assay results
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Slit2 Mutation:  2 strains or lines available
Original:  J:73904 Plump AS, et al., Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system. Neuron. 2002 Jan 17;33(2):219-32
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory