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Targeted Allele Detail
Symbol: Tff1tm1Mrio
Name: trefoil factor 1; targeted mutation 1, Marie-Christine Rio
MGI ID: MGI:2179220
Synonyms: mpS2-, TFF1-
Gene: Tff1  Location: Chr17:31161396-31165053 bp, - strand  Genetic Position: Chr17, 15.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:35923
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsExon 2 of this gene was disrupted by the insertion of a neo cassette via homologous recombination. Northern blot analysis detected mutant transcript from the stomachs of homozygous mutant animals. Western blot of gastric cytosol and immunohistochemistry of stomach from homozygous mutant animals did not detect protein product. (J:35923)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tff1 Mutation:  3 strains or lines available
Original:  J:35923 Lefebvre O, et al., Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein [see comments]. Science. 1996 Oct 11;274(5285):259-62
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory