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Lama4tm1Ktry
Targeted Allele Detail
Summary
Symbol: Lama4tm1Ktry
Name: laminin, alpha 4; targeted mutation 1, Karl Tryggvason
MGI ID: MGI:2179127
Synonyms: Lama4-, Lama4tm1Blp
Gene: Lama4  Location: Chr10:38841511-38986184 bp, + strand  Genetic Position: Chr10, 20.02 cM
Alliance: Lama4tm1Ktry page
Cardiomyocyte degeneration and fibrosis in the 40 week old Lama4tm1Ktry/Lama4tm1Ktry heart

Show the 7 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:74287
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe promoter region and exons 1 and 2 were replaced with a neomycin cassette via homologous recombination. Northern blot verified the absence of gene transcript in muscle and heart from homozygous mutant animals. Immunostaining of capillary basement membrane from homozygous mutants did not detect protein product. (J:74287)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lama4 Mutation:  113 strains or lines available
References
Original:  J:74287 Thyboll J, et al., Deletion of the laminin alpha4 chain leads to impaired microvessel maturation. Mol Cell Biol. 2002 Feb;22(4):1194-202
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory