Spo11^tm1Mjn
Targeted Allele Detail

Summary

• Symbol: Spo11^tm1Mjn
• Name: SPO11 initiator of meiotic double stranded breaks; targeted mutation 1, Maria Jasin
• MGI ID: MGI:2178805
• Synonyms: Spo11-, Spo11^tm1Sky, Spo^tm1M
• Gene: Spo11 Location: Chr2:172819493-172835369 bp, + strand Genetic Position: Chr2, 95.64 cM, cytoband H4
• Alliance: Spo11^tm1Mjn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65880
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 of this gene were replaced with a neomycin resistance cassette via homologous recombination thus deleting the putative catalytic tyrosine in exon 5. Northern blot assay failed to detect gene transcripts in testes of homozygous mutant males. (J:65880)

Expression

In Mice Carrying this Mutation:	3 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Spo11 Mutation: 20 strains or lines available

References

• Original: J:65880 Baudat F, et al., Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking spo11. Mol Cell. 2000 Nov;6(5):989-98
• All: 69 reference(s)