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Crhr2tm1Mpsp
Targeted Allele Detail
Nomenclature
Symbol: Crhr2tm1Mpsp
Name: corticotropin releasing hormone receptor 2; targeted mutation 1, Mary P Stenzel-Poore
MGI ID: MGI:2178619
Synonyms: CRF2 KO
Gene: Crhr2  Location: Chr6:55090049-55133016 bp, - strand  Genetic Position: Chr6, 27.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61510
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe exons encoding transmembrane domains 3-5 and surrounding sequence were replaced with a neo cassette via homologous recombination. (J:61510)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crhr2 Mutation:  13 strains or lines available
References
Original:  J:61510 Coste SC, et al., Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet. 2000 Apr;24(4):403-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory