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Crhr2tm1Klee
Targeted Allele Detail
Nomenclature
Symbol: Crhr2tm1Klee
Name: corticotropin releasing hormone receptor 2; targeted mutation 1, Kuo-Fen Lee
MGI ID: MGI:2178545
Synonyms: CRFR2 KO
Gene: Crhr2  Location: Chr6:55090049-55133016 bp, - strand  Genetic Position: Chr6, 27.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:61484
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing exons 10-12, which encode part of transmembrane domain 5, through the end of the transmembrane domain. Binding assays on sections of adult homozygous brain confirmed that no functional protein was expressed from this allele. (J:61484)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Crhr2 Mutation:  14 strains or lines available
References
Original:  J:61484 Bale TL, et al., Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet. 2000 Apr;24(4):410-4
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory