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Targeted Allele Detail
Symbol: Grid2tm1Mim
Name: glutamate receptor, ionotropic, delta 2; targeted mutation 1, Masayoshi Mishina
MGI ID: MGI:2178052
Synonyms: delta2-, GluRdelta2-, GluRdelta2 mutant
Gene: Grid2  Location: Chr6:63256006-64704321 bp, + strand  Genetic Position: Chr6, 29.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:24975
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced a genomic DNA fragment containing exon M3, which encodes a putative transmembrane segment. In situ hybridization analysis on brain of homozygous mice demonstrated that no normal transcript was produced from this allele. Western blot analysis on total cerebellar proteins derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:24975)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Grid2 Mutation:  22 strains or lines available
Original:  J:24975 Kashiwabuchi N, et al., Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice. Cell. 1995 Apr 21;81(2):245-52
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory