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Hoxd12tm2Ddu
Targeted Allele Detail
Nomenclature
Symbol: Hoxd12tm2Ddu
Name: homeobox D12; targeted mutation 2, Denis Duboule
MGI ID: MGI:2177960
Synonyms: Hoxd-12lac
Gene: Hoxd12  Location: Chr2:74675013-74677705 bp, + strand  Genetic Position: Chr2, 44.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36770
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsA lacZ reporter was inserted in frame with the Hoxd12 gene, at the StyI site of the first exon. In addition, a loxP-PGKneo-loxP cassette was inserted next to the lacZ cassette, in the same transcriptional orientation. Excision of the selectable marker was conducted and the resultant clones were injected into blastocysts and transferred to the germ line. The resultant targeted allele had no deletion of genomic sequences. (J:36770)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hoxd12 Mutation:  8 strains or lines available
References
Original:  J:36770 Kondo T, et al., Function of posterior HoxD genes in the morphogenesis of the anal sphincter. Development. 1996 Sep;122(9):2651-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/23/2020
MGI 6.15
The Jackson Laboratory