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Gata1tm2.1Sho
Targeted Allele Detail
Nomenclature
Symbol: Gata1tm2.1Sho
Name: GATA binding protein 1; targeted mutation 2.1, Stuart Orkin
MGI ID: MGI:2177587
Synonyms: deltaneodeltaHS, deltaneo deltaHS, Gata1deltaneodeltaHS, GATA-1 knock-down
Gene: Gata1  Location: ChrX:7959260-7978071 bp, - strand  Genetic Position: ChrX, 3.59 cM, cytoband A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41605
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele is similar to Gata1tm2Sho but the loxP flanked neomycin selection cassette was deleted in ES cells by transient Cre expression prior to the production of chimeric mice. RT-PCR shows that expression is reduced in megakaryocytes. (J:41605)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata1 Mutation:  39 strains or lines available
References
Original:  J:41605 Shivdasani RA, et al., A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1;16(13):3965-73
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory