Gata1tm2.1Sho
Targeted Allele Detail
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Symbol: |
Gata1tm2.1Sho |
Name: |
GATA binding protein 1; targeted mutation 2.1, Stuart Orkin |
MGI ID: |
MGI:2177587 |
Synonyms: |
deltaneodeltaHS, deltaneo deltaHS, Gata1deltaneodeltaHS, GATA-1 knock-down |
Gene: |
Gata1 Location: ChrX:7825504-7842844 bp, - strand Genetic Position: ChrX, 3.59 cM, cytoband A2
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Alliance: |
Gata1tm2.1Sho page
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Germline Transmission: |
Earliest citation of germline transmission:
J:41605
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: This allele is similar to Gata1tm2Sho but the loxP flanked neomycin selection cassette was deleted in ES cells by transient Cre expression prior to the production of chimeric mice. RT-PCR shows that expression is reduced in megakaryocytes.
(J:41605)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Gata1 Mutation: |
44 strains or lines available
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Original: |
J:41605 Shivdasani RA, et al., A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J. 1997 Jul 1;16(13):3965-73 |
All: |
19 reference(s) |
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