Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm2.1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
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hematopoietic system
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• early megakaryocyte maturation is blocked and proplatelet formation in culture is rare
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Allelic Composition |
Gata1tm2.1Sho/Gata1+
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm2.1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
|
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hematopoietic system
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• large increase in megakaryocytes in hematopoietic tissues, presumably because of mosaicism resulting from random X inactivation
• however, normal numbers of platelets
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• proliferation of megakaryocyte progenitors is greatly enhanced in fetal livers, presumably because of mosaicism resulting from random X inactivation
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cellular
Allelic Composition |
Gata1tm2.1Sho/Y
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm2.1Sho mutation
(0 available);
any
Gata1 mutation
(44 available)
|
|
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hematopoietic system
N |
• mutants do not develop anemia and exhibit almost normal viability
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• megakaryocytes are smaller than normal, have scant cytoplasm and condensed nuclei
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• maturation of megakaryocytes is arrested
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• 10-fold increase in megakaryocytes in the spleen and bone marrow
• excess of abnormal megakaryocytes in the yolk sac and early fetal liver
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• proliferation of megakaryocyte progenitors is greatly enhanced in fetal livers
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• platelet numbers are reduced to about 15% of normal
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cellular
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• maturation of megakaryocytes is arrested
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