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Targeted Allele Detail
Symbol: Dntttm1Gfn
Name: deoxynucleotidyltransferase, terminal; targeted mutation 1, Susan Gilfillan
MGI ID: MGI:2177306
Synonyms: TdT-
Gene: Dntt  Location: Chr19:41029275-41059523 bp, + strand  Genetic Position: Chr19, 34.32 cM
Germline Transmission:  Earliest citation of germline transmission: J:14407
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 4. RT-PCR and in situ hybridization analyses demonstrated that no detectable transcript was produced from this allele, and immunocytochemistry on thymocytes derived from homozygous mice confirmed that no detectable protein was expressed from this allele. (J:14407)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dntt Mutation:  18 strains or lines available
Original:  J:14407 Gilfillan S, et al., Mice lacking TdT: mature animals with an immature lymphocyte repertoire [published erratum appears in Science 1993 Dec 24;262(5142):1957]. Science. 1993 Aug 27;261(5125):1175-8
All:  21 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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