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Waptm1(cre)Arge
Targeted Allele Detail
Summary
Symbol: Waptm1(cre)Arge
Name: whey acidic protein; targeted mutation 1, Argiris Efstratiadis
MGI ID: MGI:2177210
Synonyms: Wapcre
Gene: Wap  Location: Chr11:6585482-6588637 bp, - strand  Genetic Position: Chr11, 4.61 cM
Alliance: Waptm1(cre)Arge page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70564
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Waptm1(cre)Arge expression driven by 1 gene
 
Mutation detailsA cre gene followed by a neomycin selection cassette was inserted into the 5' noncoding region of the gene. Activity assays demonstrated that Cre recombinase activity was detectable in mammary gland of heterozygous and homozygous mice. (J:70564)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wap (mouse)
Summary of all recombinase alleles driven by Wap.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Tumor Data
List all tumor models in MMHCdb carrying Waptm1(cre)Arge
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wap Mutation:  33 strains or lines available
References
Original:  J:70564 Ludwig T, et al., Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice. Oncogene. 2001 Jul 5;20(30):3937-48
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory