Msra^tm1Jmo
Targeted Allele Detail

Summary

• Symbol: Msra^tm1Jmo
• Name: methionine sulfoxide reductase A; targeted mutation 1, Jackob Moskovitz
• MGI ID: MGI:2177027
• Synonyms: MsrA^-, MsrA1-
• Gene: Msra Location: Chr14:64360074-64693352 bp, - strand Genetic Position: Chr14, 33.36 cM
• Alliance: Msra^tm1Jmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72532
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was used to disrupt the sequence of exon 2, which encodes the active site of the protein. Western analysis confirmed a lack of protein. The presence of enzymatic activity in tissues from homozygous mutant tissue, indicated the presence of another form of the enzyme. (J:72532)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Msra Mutation: 35 strains or lines available

References

• Original: J:72532 Moskovitz J, et al., Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5
• All: 33 reference(s)