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Msratm1Jmo
Targeted Allele Detail
Nomenclature
Symbol: Msratm1Jmo
Name: methionine sulfoxide reductase A; targeted mutation 1, Jackob Moskovitz
MGI ID: MGI:2177027
Synonyms: MsrA-, MsrA1-
Gene: Msra  Location: Chr14:64122625-64455903 bp, - strand  Genetic Position: Chr14, 33.36 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:72532
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was used to disrupt the sequence of exon 2, which encodes the active site of the protein. Western analysis confirmed a lack of protein. The presence of enzymatic activity in tissues from homozygous mutant tissue, indicated the presence of another form of the enzyme. (J:72532)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Msra Mutation:  18 strains or lines available
References
Original:  J:72532 Moskovitz J, et al., Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):12920-5
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/29/2020
MGI 6.15
The Jackson Laboratory