Analysis Tools
growth/size/body
| N |
• mice exhibit normal growth regardless of methionine content in diet
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Allele Symbol Allele Name Allele ID |
Msratm1Jmo targeted mutation 1, Jackob Moskovitz MGI:2177027 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal growth regardless of methionine content in diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 10% reduction in survival under hypoxia
• 40% reduction in survival under normotensive conditions
• all are dead by 23 months of age
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• measured as an increase in carbonylated protein
• sensitivity to oxidative stress increased in kidney, liver, and brain in particular
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• under conditions of hyperoxia thioredoxin reductase levels in the liver increase less than they do in controls (2X vs 3 X)
• thioredoxin reductase levels in the brain drop 40% under hyperoxia conditions whereas they are unaffected in controls
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• after 6 months of age, homozygous mice walk on the tips of their toes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• in mice fed a diet with 0.10% or 0.15% methionine unlike single homozygotes
• however, mice fed a diet with 0.45% methionine exhibit normal growth
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• in mice fed a diet with 0.10% or 0.15% methionine unlike single homozygotes
• however, mice fed a diet with 0.45% methionine exhibit normal growth
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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