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Targeted Allele Detail
Symbol: Leprtm1.1Rck
Name: leptin receptor; targeted mutation 1.1, Jeffrey M Friedman
MGI ID: MGI:2176775
Synonyms: ObRdelta
Gene: Lepr  Location: Chr4:101717404-101815352 bp, + strand  Genetic Position: Chr4, 46.96 cM
Germline Transmission:  Earliest citation of germline transmission: J:72241
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Leprtm1.1Rck in which exon 1 and flanking sequences were deleted in the germline by crossing mice carrying this allele to mice carrying Tg(EIIa-Cre)1Lmgd. (J:72241)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Lepr Mutation:  29 strains or lines available
Original:  J:72241 Cohen P, et al., Selective deletion of leptin receptor in neurons leads to obesity. J Clin Invest. 2001 Oct;108(8):1113-21
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory