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Targeted Allele Detail
Symbol: Egftm1Dle
Name: epidermal growth factor; targeted mutation 1, David C Lee
MGI ID: MGI:2176530
Gene: Egf  Location: Chr3:129677574-129755322 bp, - strand  Genetic Position: Chr3, 58.5 cM
Germline Transmission:  Earliest citation of germline transmission: J:54980
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced a genomic fragment containing exon 20, which encodes the first two disulfide loops. Northern blot analysis on RNA derived from salivary gland and kidney of homozygous mice demonstrated that negligible amounts of transcipt is produced from this allele. Western blot analysis on samples derived from salivary gland of homozygous mice confirmed that no detectable protein is expressed from this allele. (J:54980)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Egf Mutation:  2 strains or lines available
Original:  J:54980 Luetteke NC, et al., Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development. Development. 1999 Jun;126(12):2739-50
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory