Runx2^tm1Mjo
Targeted Allele Detail

Nomenclature

• Symbol: Runx2^tm1Mjo
• Name: runt related transcription factor 2; targeted mutation 1, Michael J Owen
• MGI ID: MGI:2176465
• Synonyms: Cbfa1-, Runx2-, Runx2^LacZ
• Gene: Runx2 Location: Chr17:44806874-45125684 bp, - strand Genetic Position: Chr17, 21.33 cM

Trabecular bone and clavicle analysis in various mice with Runx2^tm1Mjo and/or Hivep3^tm1Glm alleles

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40784
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Insertion of an IRES-lacZ-neomycin resistance cassette into the exon encoding the Q/A repeat domain placed lacZ under the control of the endogenous promoter. (J:40784)

Disease models

Expression

In Mice Carrying this Mutation:	278 assay results
In Structures Affected by this Mutation:	33 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Runx2 Mutation: 18 strains or lines available

Notes

ES cell line = GK129 or R1.3

References

• Original: J:40784 Otto F, et al., Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development. Cell. 1997 May 30;89(5):765-71
• All: 61 reference(s)