Runx2^tm1Mjo
Targeted Allele Detail

Nomenclature

Symbol:	Runx2^tm1Mjo
Name:	runt related transcription factor 2; targeted mutation 1, Michael J Owen
MGI ID:	MGI:2176465
Synonyms:	Cbfa1-, Runx2-, Runx2^LacZ
Gene:	Runx2  Location: Chr17:44495987-44814797 bp, - strand  Genetic Position: Chr17, 21.33 cM

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:40784
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	Not Specified

Mutation description

Allele Type:		Targeted (Null/knockout, Reporter)
Mutation:		Insertion
		Mutation details: Insertion of an IRES-lacZ-neomycin resistance cassette into the exon encoding the Q/A repeat domain placed lacZ under the control of the endogenous promoter. (J:40784)

Disease models

Expression

In Mice Carrying this Mutation:

210 assay results

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx2 Mutation:	2 strains or lines available

Notes

ES cell line = GK129 and R1.3

References

Original:	J:40784 Otto F, et al., Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development [see comments]. Cell. 1997 May 30;89(5):765-71
All:	43 reference(s)