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Targeted Allele Detail
Symbol: Dmc1tm1Jcs
Name: DNA meiotic recombinase 1; targeted mutation 1, John C Schimenti
MGI ID: MGI:2176331
Synonyms: Dmc1-
Gene: Dmc1  Location: Chr15:79445698-79489310 bp, - strand  Genetic Position: Chr15, 37.79 cM, cytoband E
Germline Transmission:  Earliest citation of germline transmission: J:47308
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing sequences encoding the conserved DNA binding motif required for protein activity. RT-PCR analysis on RNA derived from testis of homozygous males demonstrated that no detectable transcript was produced from this allele. (J:47308)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 6 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmc1 Mutation:  12 strains or lines available
Original:  J:47308 Pittman DL, et al., Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol Cell. 1998 Apr;1(5):697-705
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
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