About   Help   FAQ
Dmc1tm1Jcs
Targeted Allele Detail
Nomenclature
Symbol: Dmc1tm1Jcs
Name: DNA meiotic recombinase 1; targeted mutation 1, John C Schimenti
MGI ID: MGI:2176331
Synonyms: Dmc1-
Gene: Dmc1  Location: Chr15:79561500-79605084 bp, - strand  Genetic Position: Chr15, 37.79 cM, cytoband E
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47308
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced a genomic fragment containing sequences encoding the conserved DNA binding motif required for protein activity. RT-PCR analysis on RNA derived from testis of homozygous males demonstrated that no detectable transcript was produced from this allele. (J:47308)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dmc1 Mutation:  10 strains or lines available
References
Original:  J:47308 Pittman DL, et al., Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol Cell. 1998 Apr;1(5):697-705
All:  21 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory