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Targeted Allele Detail
Symbol: Pou4f3tm1Rsd
Name: POU domain, class 4, transcription factor 3; targeted mutation 1, Michael G Rosenfeld
MGI ID: MGI:2176270
Synonyms: Brn3.1-
Gene: Pou4f3  Location: Chr18:42394539-42397249 bp, + strand  Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
Germline Transmission:  Earliest citation of germline transmission: J:33502
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette replaced a 2.4 kb genomic fragment containing the entire coding sequence of the gene. In situ hybridization analysis confirmed absence of mRNA in trigeminal ganglia of mutant mice. (J:33502)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou4f3 Mutation:  5 strains or lines available
Homozygous mutant mice have a similar phenotype to dreidel mice, which are homozygous for Pou4f3ddl.

Phenotypic Similarity to Human Syndrome: Hereditary Deafness J:207266.

Original:  J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory