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Targeted Allele Detail
Symbol: Chst3tm1Tmu
Name: carbohydrate sulfotransferase 3; targeted mutation 1, Takashi Muramatsu
MGI ID: MGI:2176247
Synonyms: C6st-
Gene: Chst3  Location: Chr10:60181532-60219260 bp, - strand  Genetic Position: Chr10, 29.7 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:73698
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences in exon III encoding part of the catalytic domain. Northern blot analysis of spleen did not detect mRNA in homozygous mutant mice. Protein activity was not detected in spleen, lung, and lymph nodes of homozygous mutant mice. (J:73698)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Chst3 Mutation:  15 strains or lines available
Original:  J:73698 Uchimura K, et al., Functional analysis of the chondroitin 6-sulfotransferase gene in relation to lymphocyte subpopulations, brain development, and oversulfated chondroitin sulfates. J Biol Chem. 2002 Jan 11;277(2):1443-50
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.13
The Jackson Laboratory