Phenotypes associated with this allele

• Allele Symbol: Chst3^tm1Tmu
• Allele Name: targeted mutation 1, Takashi Muramatsu
• Allele ID: MGI:2176247
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chst3^tm1Tmu/Chst3^tm1Tmu	involves: 129S2/SvPas	MGI:5615634
hm2	Chst3^tm1Tmu/Chst3^tm1Tmu	involves: 129S2/SvPas * 129X1/SvJ	MGI:2663202

Genotype
MGI:5615634

hm1

• Allelic Composition: Chst3^tm1Tmu/Chst3^tm1Tmu
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased T cell proliferation ( J:217719 )

reproductive system

abnormal ovarian folliculogenesis ( J:217719 )

♀ • delayed maturation

immune system

increased T cell proliferation ( J:217719 )

decreased neutrophil cell number ( J:217719 )

lymph node hypoplasia ( J:217719 )

nervous system

decreased prepulse inhibition ( J:217719 )

• hearing impaired prepulse inhibition

behavior/neurological

decreased aggression towards mice ( J:217719 )

• less aggressive in social dominance

endocrine/exocrine glands

abnormal ovarian folliculogenesis ( J:217719 )

♀ • delayed maturation

hematopoietic system

increased T cell proliferation ( J:217719 )

decreased neutrophil cell number ( J:217719 )

skeleton

abnormal bone marrow morphology ( J:217719 )

• increased frequency of CD5+ cells in bone marrow

Genotype
MGI:2663202

hm2

• Allelic Composition: Chst3^tm1Tmu/Chst3^tm1Tmu
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ

immune system

decreased T cell number ( J:73698 )

• reduction in number of naive T cells in the spleen of 5-6 week old mutant animals

• however, normal spleen morphology and lymphocyte trafficking into secondary lymph nodes

nervous system

nervous system phenotype ( J:73698 )

N • normal brain development and morphology, particularly the organization of the cerebral cortex and orientation of processes for pyramidal cells

hematopoietic system

decreased T cell number ( J:73698 )

• reduction in number of naive T cells in the spleen of 5-6 week old mutant animals

• however, normal spleen morphology and lymphocyte trafficking into secondary lymph nodes