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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chst3tm1Tmu
targeted mutation 1, Takashi Muramatsu
MGI:2176247
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chst3tm1Tmu/Chst3tm1Tmu involves: 129S2/SvPas MGI:5615634
hm2
 		Chst3tm1Tmu/Chst3tm1Tmu involves: 129S2/SvPas * 129X1/SvJ MGI:2663202


Genotype
MGI:5615634
hm1
Allelic
Composition		 Chst3tm1Tmu/Chst3tm1Tmu
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst3tm1Tmu mutation (1 available); any Chst3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular

reproductive system
abnormal ovarian folliculogenesis ( J:217719 )
• delayed maturation

immune system

nervous system
decreased prepulse inhibition ( J:217719 )
• hearing impaired prepulse inhibition

behavior/neurological
decreased aggression towards mice ( J:217719 )
• less aggressive in social dominance

endocrine/exocrine glands
abnormal ovarian folliculogenesis ( J:217719 )
• delayed maturation

hematopoietic system

skeleton
abnormal bone marrow morphology ( J:217719 )
• increased frequency of CD5+ cells in bone marrow




Genotype
MGI:2663202
hm2
Allelic
Composition		 Chst3tm1Tmu/Chst3tm1Tmu
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chst3tm1Tmu mutation (1 available); any Chst3 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell number ( J:73698 )
• reduction in number of naive T cells in the spleen of 5-6 week old mutant animals
• however, normal spleen morphology and lymphocyte trafficking into secondary lymph nodes

nervous system
nervous system phenotype ( J:73698 )
N
• normal brain development and morphology, particularly the organization of the cerebral cortex and orientation of processes for pyramidal cells

hematopoietic system
decreased T cell number ( J:73698 )
• reduction in number of naive T cells in the spleen of 5-6 week old mutant animals
• however, normal spleen morphology and lymphocyte trafficking into secondary lymph nodes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory