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Speer6-ps1Tg(Alb-cre)21Mgn
Transgenic Allele Detail
Nomenclature
Symbol: Speer6-ps1Tg(Alb-cre)21Mgn
Name: spermatogenesis associated glutamate (E)-rich protein 6, pseudogene 1; transgene insertion 21, Mark A Magnuson
MGI ID: MGI:2176228
Synonyms: Albcre, Alb-cre, AlbCre, Alb-Cre, Albcre2, albumin-cre, crAlb, CreALB, Tg(Alb-cre)21Mg
Gene: Speer6-ps1  Location: Chr13:3186206-3189317 bp, + strand  Genetic Position: Chr13, 1.78 cM
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA)F2
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe transgene contains a 2.34 kb mouse albumin enhancer/promoter (M. Magnuson verified mouse promoter, personal communication), a nuclear localization sequence-modified Cre recombinase gene and a 2.1 kb fragment from the human growth hormone gene. The promoter is active in hepatocyte cells of the liver. 7 copies of the transgene are estimated to be present. Line 21 inserted into the gene at 3172116-3172120 (Build GRCm38/mm10) resulting in a 4 bp deletion. Founder line x has a copy number of approximately 10. (J:51826, J:253473)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Alb     Summary of all recombinase alleles driven by Alb. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Speer6-ps1 Mutation:  2 strains or lines available
References
Original:  J:51826 Postic C, et al., Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase. J Biol Chem. 1999 Jan 1;274(1):305-15
All:  713 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory