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Targeted Allele Detail
Symbol: Casp8tm1.1Yuan
Name: caspase 8; targeted mutation 1.1, Junying Yuan
MGI ID: MGI:2176089
Gene: Casp8  Location: Chr1:58795374-58847503 bp, + strand  Genetic Position: Chr1, 29.19 cM, cytoband B
Germline Transmission:  Earliest citation of germline transmission: J:49459
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is a derivative of Casp8tm1Yuan in which the loxP-flanked neomycin resistance cassette was removed by Cre-mediated recombination by mating mice carrying this allele to mice expressing Cre in the maternal germline. (J:49459)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 11 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Casp8 Mutation:  32 strains or lines available
Original:  J:49459 Varfolomeev EE, et al., Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity. 1998 Aug;9(2):267-76
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory